Synthesis of some new pyrimidine-based pyrene/benzochromene hybrids as EGFR kinase inhibitors in HCT-116 cancer cells through apoptosis
Yassin Adam A. Mohammed, Nabila A. Kheder, Mohamed S. Nafie, Ashraf A. Abbas, Kamal M. Dawood
Abstract
= 72.3 nM). Compound 4b treatment induced apoptosis in HCT-116 cancer cells by 30.2-fold, arresting the cell cycle at the G1-phase. It upregulated the apoptosis-related genes using the RT-PCR. Finally, a molecular docking study highlighted the binding interactions with key amino acids inside the EGFR binding site.
Topics & Concepts
PyrimidinePyreneApoptosisChemistryCancer researchHybridCancer cellKinaseCancerCell cultureBiochemistryCombinatorial chemistryBiologyGeneticsBotanyOrganic chemistrySynthesis and biological activityMulticomponent Synthesis of HeterocyclesSynthesis and Biological Activity