Divergent g-C<sub>3</sub>N<sub>4</sub>-catalyzed Reactions of Quinoxalin-2(1<i>H</i>)-ones with <i>N</i>-Aryl Glycines under Visible Light: Solvent-Controlled Hydroaminomethylation and Annulation
Ya‐Feng Si, Xiaolan Chen, Xiaoyang Fu, Kai Sun, Xiaojie Song, Lingbo Qu, Bing Yu
Abstract
An effective and simple visible light-induced heterogeneous g-C3N4-catalyzed decarboxylative reaction of quinoxalin-2(1H)-ones with N-aryl glycines was developed. When the reaction was performed in DMSO/H2O and EtOH, the products dihydroquinoxalin-2(1H)-ones and tetrahydroimidazo[1,5-a]quinoxalin-4(5H)-ones were unprecedentedly obtained in good yields, respectively. This solvent-dependent system offers advantages, including simple and easy operation, short reaction time, high chemoselectivity, a recyclable catalyst, metal-/base-/oxidant-free, and mild reaction conditions.
Topics & Concepts
ChemoselectivityCatalysisChemistryArylSolventReaction conditionsCombinatorial chemistryBase (topology)Medicinal chemistryOrganic chemistryAlkylMathematical analysisMathematicsSynthesis and Biological EvaluationRadical Photochemical ReactionsCatalytic C–H Functionalization Methods