Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells
Parham Ramezani-Rad, Cindi Chen, Zilu Zhu, Robert C. Rickert
Abstract
hyperstabilization as observed in B cell lymphoma. Thereby, selected GC B cells in the light zone potentially require disengagement from BCR signaling to accumulate cyclin D3 and undergo clonal expansion in the DZ.
Topics & Concepts
Cyclin D3Cyclin DCyclin A2Cyclin BCyclin D2Germinal centerCyclinCell biologyCyclin ABiologyCell cycleCyclin ECancer researchCell growthCyclin D1B cellMolecular biologyCellGeneticsAntibodyImmune Cell Function and InteractionChronic Lymphocytic Leukemia ResearchT-cell and B-cell Immunology