Cancer-associated fibroblasts downregulate type I interferon receptor to stimulate intratumoral stromagenesis
Christina Cho, Riddhita Mukherjee, Amy R. Peck, Yunguang Sun, Noreen McBrearty, Kanstantsin V. Katlinski, Jun Gui, Priya Govindaraju, Ellen Puré, Hallgeir Rui, Serge Y. Fuchs
Topics & Concepts
Downregulation and upregulationBiologyCancer researchDesmoplasiaExtracellular matrixFibroblastTransforming growth factorGene knockdownReceptorPancreatic cancerCancerInternal medicineEndocrinologyCell biologyCell cultureBiochemistryGeneMedicineGeneticsTGF-β signaling in diseasesCancer, Hypoxia, and MetabolismColorectal Cancer Treatments and Studies