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Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation

Hyeseung Lee, Robert J. Fenster, S. Sebastian Pineda, Whitney S. Gibbs, Shahin Mohammadi, José Dávila-Velderrain, F. García, Martine Therrien, Hailey S. Novis, Fan Gao, Hilary Wilkinson, Thomas Vogt, Manolis Kellis, Matthew J. LaVoie, Myriam Heiman

2020Neuron298 citationsDOIOpen Access PDF

Topics & Concepts

HuntingtinInnate immune systemTranscriptomeCell biologyMutantRNABiologyMitochondrionImmune systemCellGene expressionGeneGeneticsRNA Research and SplicingNeuroinflammation and Neurodegeneration MechanismsMitochondrial Function and Pathology
Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation | Litcius