Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation
Hyeseung Lee, Robert J. Fenster, S. Sebastian Pineda, Whitney S. Gibbs, Shahin Mohammadi, José Dávila-Velderrain, F. García, Martine Therrien, Hailey S. Novis, Fan Gao, Hilary Wilkinson, Thomas Vogt, Manolis Kellis, Matthew J. LaVoie, Myriam Heiman
Topics & Concepts
HuntingtinInnate immune systemTranscriptomeCell biologyMutantRNABiologyMitochondrionImmune systemCellGene expressionGeneGeneticsRNA Research and SplicingNeuroinflammation and Neurodegeneration MechanismsMitochondrial Function and Pathology