What's a SNP between friends: The lineage of Clostridioides difficile R20291 can effect research outcomes
Jorge Monteford, Terry W. Bilverstone, Patrick Ingle, Sheryl Philip, Sarah A. Kuehne, Nigel P. Minton
Abstract
Clostridioides difficile R20291 is the most studied PCR-Ribotype 027 isolate. The two predominant lineages of this hypervirulent strain, however, exhibit substantive phenotypic differences and possess genomes that differ by a small number of nucleotide changes. It is important that the source of R20291 is taken into account in research outcomes.
Topics & Concepts
ClostridioidesLineage (genetic)SNPBiologyGeneticsSingle-nucleotide polymorphismStrain (injury)PhenotypeGenomeComputational biologyEvolutionary biologyGeneMicrobiologyGenotypeAnatomyClostridium difficile and Clostridium perfringens researchViral gastroenteritis research and epidemiologyBacterial Identification and Susceptibility Testing