SNHG3 promotes migration, invasion, and epithelial-mesenchymal transition of breast cancer cells through the miR-186-5p/ZEB1 axis.
Qun Wan, Min Tang, Shi-Lei Sun, Jing Hu, Zijiu Sun, Yuting Fang, Tong‐Chuan He, Yan Zhang
Abstract
. Overexpression of ZEB1 triggered cellular migration and invasion behaviors. Analysis of the mechanism underlying these effects suggested that SNHG3 is an effective sink for miR-186-5p and modulates ZEB1 repression, conferring an additional level to its post-transcriptional regulation. In conclusion, SNHG3 promotes the migration and invasion of breast cancer cells through miR-186-5p/ZEB1 regulation and the induction of the epithelial to mesenchymal transition, indicating that SNHG3 is a potential treatment target for breast cancer.
Topics & Concepts
Gene knockdownOncogeneEpithelial–mesenchymal transitionCancer researchBreast cancerBiologyDownregulation and upregulationCancerMetastasisCell cultureGeneCell cycleGeneticsCancer-related molecular mechanisms researchCircular RNAs in diseasesRNA Research and Splicing