A polysaccharide from <i>Sargassum pallidum</i> reduces obesity in high-fat diet-induced obese mice by modulating glycolipid metabolism
Dan Yuan, Qiang Huang, Chao Li, Xiong Fu
Abstract
for 8 weeks, respectively. The results showed that oral administration of D-SPP not only dramatically suppressed body weight gain and reduced the fasting blood glucose level, but also lowered the levels of serum and hepatic lipids in HFD-induced obese mice. Histopathological analysis showed that D-SPP significantly prevented liver fat accumulation and reduced white adipose hypertrophy and adipocyte size. Real-time quantitative polymerase chain reaction (RT-qPCR) analysis indicated that D-SPP intervention significantly down-regulated the relative expressions of adipogenesis genes. Specifically, the peroxisome proliferator-activated receptors-γ (PPAR-γ), sterol regulatory element-binding protein-1 (Srebp-1c), acetyl-CoA carboxylase-1(ACC1) and fatty acid synthase (FAS) in the liver of obese mice were decreased by 68, 53, 73, and 78%, respectively. These findings suggest that D-SPP might potentially be used as a promising dietary supplement for ameliorating obesity.