Prognostic roles of metabolic reprogramming-associated genes in patients with hepatocellular carcinoma
Lijuan Cui, Huan Xue, Zhitong Wen, Zhihong Lu, Yunfeng Liu, Yi Zhang
Abstract
were screened via univariate Cox regression analysis and a LASSO Cox regression model, which divided patients into high- and low-risk groups. Furthermore, gene set enrichment analysis revealed that significantly-enriched gene ontology terms and pathways involving high-risk patients were focused on regulation of nucleic and fatty acid metabolism. Taken together, our study identified five metabolic genes related to survival, which can be used to predict the prognosis of patients with hepatocellular carcinoma. These genes may play essential roles in metabolic microenvironment regulation, and represent potentially important candidate targets in metabolic therapy.
Topics & Concepts
Hepatocellular carcinomaReprogrammingGeneCancer researchOncologyInternal medicineBiologyMedicineGeneticsCancer, Hypoxia, and MetabolismMetabolism, Diabetes, and CancerEpigenetics and DNA Methylation