Dopamine-derived nanoparticles for the protection of irradiation-induced intestinal injury by maintaining intestinal homeostasis
Shuhan Jia, Suhe Dong, Heng Liu, Huijie Yu, Zhongmin Chen, Sinian Wang, Wei Li, Renjun Peng, Fengsheng Li, Qisheng Jiang, Jianjun Liu
Abstract
intestinal stem cells (ISCs) and promoted cell regeneration after IR, which indicated that the regeneration ability of ISCs was maintained and the repair of intestinal structure and function was promoted. Finally, PDA-NPs significantly suppressed the apoptosis, inflammatory pyroptosis and DNA damage of intestinal cells induced by ionizing radiation. Altogether, our study suggested that PDA-NPs may have great potential in protecting the intestines from ionizing radiation damage.
Topics & Concepts
ChemistryOxidative stressApoptosisReactive oxygen speciesInflammationCryptBiophysicsStem cellIntestinal epitheliumRegeneration (biology)Cell biologyBiochemistryImmunologyEpitheliumMedicineBiologyPathologyInternal medicineEffects of Radiation ExposureHydrogen's biological and therapeutic effectsMesenchymal stem cell research