A light-controlled multi-step drug release nanosystem targeting tumor hypoxia for synergistic cancer therapy
Bin Zhang, Zichen Xu, Wen Zhou, Zhikun Liu, Jian Zhao, Shao-Hua Gou
Abstract
studies on MDA-MB-231 xenograft models revealed that CC5-RuCa with preferential accumulation in the tumor exhibited highly efficient tumor regression through the synergistic effect of photodynamic therapy and hypoxia-activated chemotherapy.
Topics & Concepts
ProdrugHypoxia (environmental)Photodynamic therapyTumor hypoxiaChemistryCancer researchDrugMetastasisIn vivoCancer cellPharmacologyCancerMedicineRadiation therapyInternal medicineBiochemistryOxygenBiologyOrganic chemistryBiotechnologyNanoplatforms for cancer theranosticsCancer, Hypoxia, and MetabolismPhotodynamic Therapy Research Studies