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How deeply should we analyze non-covalent interactions?

Timothy Clark

2023Journal of Molecular Modeling18 citationsDOIOpen Access PDF

Abstract

Abstract Context Just how much effort and detail should we invest in analyzing interactions of the order of 5 kcal mol −1 ? This comment attempts to provide a conciliatory overview of what is often a contentious field and to pose some questions that I hope will eventually lead at least to some consensus. Methods This is an opinion article without calculations or data.

Topics & Concepts

Field (mathematics)EpistemologyOrder (exchange)Data scienceSociologyComputer scienceManagement sciencePsychologyEngineeringPhilosophyBusinessMathematicsFinancePure mathematicsCrystallography and molecular interactionsChemical Thermodynamics and Molecular StructureThermodynamic properties of mixtures
How deeply should we analyze non-covalent interactions? | Litcius