Chiral 3,3,3′,3′-Tetramethyl-1,1′-Spirobiindanyl Cyclopentadienyl (TMSCp) Ligands: Design, Synthesis, and Applications
Weicong Guo, Xingying Pang, Ji‐Jun Jiang, Jun Wang
Abstract
Chiral cyclopentadienyl (Cp) rhodium(III) are powerful catalysts for achieving asymmetric C-H activation. This paper describes the design and synthesis of a new type of chiral Cp ligand bearing a chiral 3,3,3',3'-tetramethyl-1,1'-spirobiindanyl backbone. It features convenient synthesis, easy modification, and relatively low cost. Moreover, it holds great potential in achieving asymmetric C-H activation as exemplified by four examples examined in this work.
Topics & Concepts
Cyclopentadienyl complexChemistryRhodiumCatalysisLigand (biochemistry)Combinatorial chemistryEnantioselective synthesisStereochemistryOrganic chemistryReceptorBiochemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsAsymmetric Hydrogenation and Catalysis