lncRNA SLC7A11-AS1 Promotes Chemoresistance by Blocking SCFβ-TRCP-Mediated Degradation of NRF2 in Pancreatic Cancer
Qingzhu Yang, Kai Li, Xuemei Huang, Chen Zhao, Yu Mei, Xinyuan Li, Lin Jiao, Huanjie Yang
Abstract
-mediated ubiquitination and degradation of NRF2, leading to a low level of intracellular ROS, which is required for the maintenance of cancer stemness. These findings suggest SLC7A11-AS1 as a therapeutic target to overcome gemcitabine resistance for PDAC treatment.
Topics & Concepts
GemcitabinePancreatic cancerCancer researchGene knockdownCancer cellBiologyCancerCell cultureGeneticsCancer-related molecular mechanisms researchRNA modifications and cancerGenomics, phytochemicals, and oxidative stress