Association of serum C-reactive protein (CRP) and D-dimer concentration on the severity of COVID-19 cases with or without diabetes: a systematic review and meta-analysis
Hoimonti Debi, Zarin Tasnim Itu, Mohammad Tohidul Amin, Fahad Hussain, Mohammad Salim Hossain
Abstract
INTRODUCTION: Coronavirus disease (COVID-19) is a highly contagious disease that poses major public health risks. Fewer studies link high CRP and D-dimer levels to severe COVID-19 infection. Therefore, this study investigates the association of serum CRP and D-dimer concentration with COVID-19 severity in diabetic and non-diabetic patients. AREAS COVERED: 88%). There was no publication bias. CRP and D-dimer rose with age in COVID-19 diabetic and non-diabetic patients. EXPERT OPINION: Overall, the serum CRP and D-dimer concentration in COVID-19 diabetic patients was significantly higher than non-diabetic patients indicating severe illness.
Topics & Concepts
MedicineMeta-analysisDiabetes mellitusInternal medicineCoronavirus disease 2019 (COVID-19)Publication biasD-dimerC-reactive proteinSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)DiseaseGastroenterologyEndocrinologyInfectious disease (medical specialty)InflammationCOVID-19 Clinical Research StudiesAdipokines, Inflammation, and Metabolic DiseasesPancreatitis Pathology and Treatment