Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2
Benedict‐Tilman Berger, Marta Amaral, Daria B. Kokh, Ariane Nunes‐Alves, Djordje Müsil, Timo Heinrich, Martin Schröder, Rebecca Neil, Jing Wang, Iva Navrátilová, Joerg Bomke, Jonathan M. Elkins, Susanne Müller, Matthias Frech, Rebecca C. Wade, Stefan Knapp
Topics & Concepts
SelectivityChemistryDissociation (chemistry)Focal adhesionBiophysicsStereochemistryRegulatorTyrosine kinaseTyrosineKinaseBiochemistryPhosphorylationReceptorBiologyGeneCatalysisPhysical chemistryCell Adhesion Molecules ResearchUbiquitin and proteasome pathwaysProtein Kinase Regulation and GTPase Signaling