Ritanserin, a potent serotonin 2A receptor antagonist, represses MEK/ERK signalling pathway to restore PAX6 production and function in aniridia-like cellular model
Keren Oved, Léa Zennaro, Orly Dorot, Johanna Zerbib, Elie Frank, Lauriane N. Roux, Dominique Brémond‐Gignac, Edward Pichinuk, Daniel Aberdam
Topics & Concepts
PAX6RitanserinAniridiaMAPK/ERK pathwayBiologyCancer researchReceptor antagonistCell biologyReceptorSignal transductionGeneticsAntagonistGeneTranscription factorRetinal Development and DisordersConnexins and lens biologyCorneal Surgery and Treatments