Design, synthesis, biological evaluation, and docking study of chromone-based phenylhydrazone and benzoylhydrazone derivatives as antidiabetic agents targeting α‐glucosidase
Meiyan Fan, Wei Yang, Lin Liu, Zhiyun Peng, Yan He, Guangcheng Wang
Topics & Concepts
ChemistryAcarboseChromoneCytotoxicityStereochemistryCircular dichroismDocking (animal)IC50In vivoProton NMRHydrazoneCarbon-13 NMREnzymeTwo-dimensional nuclear magnetic resonance spectroscopyIn vitroBiochemistryNursingBiotechnologyMedicineBiologyNatural Antidiabetic Agents StudiesComputational Drug Discovery MethodsSynthesis and biological activity