Litcius/Paper detail

YAP/TEAD inhibitor VT3989 in solid tumors: a phase 1/2 trial

Timothy A. Yap, David J. Kwiatkowski, Ibiayi Dagogo‐Jack, Michael Offin, Marjorie G. Zauderer, Robert A. Kratzke, Jayesh Desai, Amy Body, Michael Millward, Anthony W. Tolcher, Kanwal Raghav, Archie Thurston, Len Post, F. Andrew Dorr, Tracy Tang, Yufeng Li, Neelesh Sharma, Hedy L. Kindler

2025Nature Medicine32 citationsDOI

Topics & Concepts

MesotheliomaMedicineRefractory (planetary science)ProteinuriaInterimDrugUrologyInternal medicinePeripheral edemaClinical trialUrineOncologyPharmacologyAntagonistToxicityInterim analysisFood and drug administrationPazopanibAdverse effectCohortRetention ratePhases of clinical researchGastroenterologyPharmacokineticsCancer researchEdemaPeripheralKidneyHippo pathway signaling and YAP/TAZCancer-related gene regulation