The SARS-CoV-2 B.1.618 variant slightly alters the spike RBD–ACE2 binding affinity and is an antibody escaping variant: a computational structural perspective
Abbas Khan, Jianjun Gui, Waqar Ahmad, Inamul Haq, Marukh Shahid, Awais Ahmed Khan, Abdullah Shah, Arsala Khan, Liaqat Ali, Zeeshan Anwar, Muhammad Safdar, Jehad Abubaker, Nizam Uddin, Liqiang Cao, Dong‐Qing Wei, Anwar Mohammad
Abstract
This study explored the binding patterns of the wild type and B.1.618 variant using which revealed that the B.1.618 variant possess a stronger binding affinity for the host ACE2 and escape the neutralizing antibodies.
Topics & Concepts
Spike (software development)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Spike ProteinCoronavirus disease 2019 (COVID-19)Perspective (graphical)Antibody2019-20 coronavirus outbreakChemistryVirologyBiologyGeneticsComputer scienceMedicineArtificial intelligenceDiseaseInfectious disease (medical specialty)Software engineeringPathologyOutbreakSARS-CoV-2 and COVID-19 ResearchMonoclonal and Polyclonal Antibodies ResearchCOVID-19 Clinical Research Studies