Noncoding RNAs in Atopic Dermatitis: Insight Into Inflammation and Immune Regulation
Lemei Zhu, Yuqing Liu, Zhuo Gong, Bohua Zhu, Chenghao Zhang, Haoqi Zhang, Wei Liu, Shan Hui, Shuangni Duan, Pingping Bing
Abstract
Atopic dermatitis (AD) is a chronic inflammatory skin disorder affecting approximately 20% of children and 10% of adults. While previous studies have linked AD to allergen exposure, disruption of the skin barrier, and Type 2 immune responses, the precise pathophysiology of AD remains elusive, significantly limiting the effectiveness of current treatments. Noncoding RNAs (ncRNAs), a diverse group of transcripts that do not encode proteins and account for at least 98% of the human genome, are implicated in numerous physiological and pathological processes. A growing body of evidence underscores the pivotal role of ncRNAs in the pathogenesis and progression of AD. This review offers a detailed synthesis of the latest insights into the involvement of ncRNAs in AD, as well as their potential as diagnostic biomarkers and therapeutic targets.