Discovery and biological evaluation of 4,6-pyrimidine analogues with potential anticancer agents as novel colchicine binding site inhibitors
Jifa Zhang, Lun Tan, Chengyong Wu, Yuyan Li, Hao Chen, Yinghuan Liu, Yuxi Wang
Topics & Concepts
ChemistryColchicineTubulinIn vivoPyrimidineMicrotubuleBinding siteA549 cellApoptosisMicrotubule polymerizationIC50In vitroBiochemistryStereochemistryCell biologyBiologyBiotechnologyGeneticsSynthesis and biological activityQuinazolinone synthesis and applicationsSynthesis and Biological Evaluation