Distinct subpopulations of human subcutaneous adipose tissue precursor cells revealed by single-cell RNA sequencing
Adeline Divoux, Katie L. Whytock, László Halász, Meghan Hopf, Lauren M. Sparks, Timothy F. Osborne, Steven R. Smith
Abstract
Identification of distinct subpopulations of adipose-derived stem cells (ADSCs) in upper body abdominal subcutaneous (ABD) and lower body gluteofemoral subcutaneous (GF) adipose tissue depots. In ABD-ADSCs, subpopulations are more committed to adipocyte lineage. GF-ADSC subpopulations are enriched for genes involved in lipids and cholesterol metabolism. Similar depot differences were found in stem cell population identified in freshly isolated stoma vascular fraction. The repertoire of ADSCs subpopulations was different in apple-shaped versus pear-shaped women.
Topics & Concepts
Adipose tissueBiologyAdipogenesisStem cellAdipocytePopulationCell biologyEndocrinologyMedicineEnvironmental healthAdipose Tissue and MetabolismSingle-cell and spatial transcriptomicsAdipokines, Inflammation, and Metabolic Diseases