Principles and Applications of CF<sub>2</sub>X Moieties as Unconventional Halogen Bond Donors in Medicinal Chemistry, Chemical Biology, and Drug Discovery
Sebastian Vaas, Markus O. Zimmermann, Dieter Schollmeyer, Jason Stahlecker, M. Engelhardt, Janosch Rheinganz, Bernhard Drotleff, Matthias Olfert, Michael Lämmerhofer, Markus Krämer, Thilo Stehle, Frank M. Boeckler
Abstract
Br toward the P-loop, as well as chalcogen bonds. We suggest that underexplored chemical space combined with unconventional binding modes provides excellent opportunities for patentable chemotypes for therapeutic intervention.
Topics & Concepts
ChemistryChemical spaceDrug discoveryHalogen bondHalideCombinatorial chemistryComputational chemistrySolubilityArylChemical biologyChemical stabilityBinding affinitiesChalcogenHalogenMoleculeChemical shiftStereochemistryOrganic chemistryHydrogen bondPhysical chemistryReceptorAlkylBiochemistryCrystallography and molecular interactionsFluorine in Organic ChemistryStructural and Chemical Analysis of Organic and Inorganic Compounds