STING and IRF3 in stromal fibroblasts enable sensing of genomic stress in cancer cells to undermine oncolytic viral therapy
Esther N. Arwert, Emma Milford, Antonio Rullan, Stefanie Derzsi, Steven Hooper, Takuya Kato, David Mansfield, Alan Melcher, Kevin J. Harrington, Erik Sahai
Topics & Concepts
Oncolytic virusIRF3Cancer-Associated FibroblastsStingStromal cellCancer cellCell biologyBiologyCancer researchViral therapyCancerVirologyMedicineCoronavirus disease 2019 (COVID-19)ImmunologyTumor cellsGeneticsPathologyInnate immune systemImmune systemAerospace engineeringInfectious disease (medical specialty)EngineeringDiseaseinterferon and immune responsesVirus-based gene therapy researchViral Infections and Outbreaks Research