Ancestral archaea expanded the genetic code with pyrrolysine
Litao Guo, Kazuaki Amikura, Han-Kai Jiang, Takahito Mukai, Xian Fu, Yane‐Shih Wang, Patrick O’Donoghue, Dieter Söll, Jeffery M. Tharp
Abstract
will enable future efforts to engineer PylRS systems for further genetic code expansion.
Topics & Concepts
BiologyArchaeaAminoacylationGenetic codeAmino acidAminoacyl tRNA synthetaseBiochemistryGeneticsAmino Acyl-tRNA SynthetasesTransfer RNAStreptomyces coelicolorEnzymeBacteriaComputational biologyGeneRNAStreptomycesRNA and protein synthesis mechanismsGenomics and Phylogenetic StudiesRNA modifications and cancer