Synergistic Antibacterial Effect of Phage pB3074 in Combination with Antibiotics Targeting Cell Wall against Multidrug-Resistant Acinetobacter baumannii <i>In Vitro</i> and <i>Ex Vivo</i>
Jun Luo, Libo Xie, Min Yang, Min Liu, Qianyuan Li, Peng Wang, Jinhong Fan, Jing Jin, Chunhua Luo
Abstract
Combined application of phages and antibiotics cannot only effectively inhibit the appearance of phage-resistant bacteria, but also reduce the effective use concentration of antibiotics, and even make some bacteria regain sensitivity to some resistant antibiotics. Therefore, phage-antibiotic combination (PAC) could improve the antibacterial activity of individual drug, providing a new choice for clinical treatment of multidrug-resistant bacterial infections.
Topics & Concepts
AntibioticsAcinetobacter baumanniiMicrobiologyBacteriaMultiple drug resistanceBiologyAcinetobacterDrug resistanceEx vivoIn vivoAntibacterial activityPseudomonas aeruginosaBiotechnologyGeneticsBacteriophages and microbial interactionsAntibiotic Resistance in BacteriaMicrobial infections and disease research