Molecular Mechanisms Underlying the Absorption of Aglycone and Glycosidic Flavonoids in a Caco-2 BBe1 Cell Model
Hua Zhang, Yousef I. Hassan, Ronghua Liu, Lili Mats, Cheng Yang, Chunming Liu, Rong Tsao
Abstract
prediction model also supported these observations. The absorption of glycosides, especially diglycosides but not the aglycones, was significantly blocked by SGLT1 and GLUT2 inhibitors (phloridzin and phloretin) and further validated in SGLT1 knockdown Caco-2 BBe1 cells.
Topics & Concepts
AglyconeChemistryGLUT2GlycosideBiochemistryPhloretinCaco-2StereochemistryCellGene expressionGenePhytochemicals and Antioxidant ActivitiesNatural Antidiabetic Agents StudiesPlant Gene Expression Analysis