3D printed heterogeneous hybrid hydrogel scaffolds for sequential tumor photothermal-chemotherapy and wound healing
Langtao Xu, You Chen, Peng Zhang, Junjie Tang, Yifan Xue, Hongsheng Luo, Rui Dai, Jinlong Jin, Jie Liu
Abstract
in the hybrid bioink, providing superior photothermal effects to the scaffold. After coating with a thermosensitive gelatin hydrogel loaded with the chemotherapeutic drug doxorubicin (DOX), the heterogeneous hydrogel scaffold could accelerate drug release under photothermal triggering and achieve photothermal-chemotherapy to suppress tumor cell proliferation and recurrence after surgical resection. Subsequently, the printed porous hybrid hydrogel scaffold enhanced HUVEC proliferation and migration, as well as tissue ingrowth, promoting wound healing following surgery. In the same mouse model, the sequential treatment with the heterogeneous SA-GG@PDA + DOX hydrogel scaffold was tested. The fabrication of the heterogeneous SA-GG@PDA + DOX hydrogel scaffold with multifunctional capabilities seemed to be a potential technique for preventing tumor recurrence and promoting wound healing following surgery.