Reducing the antigen-independent toxicity of antibody-drug conjugates by minimizing their non-specific clearance through PEGylation
Jessica K. Simmons, Patrick Burke, Julia H. Cochran, Paul G. Pittman, Robert P. Lyon
Topics & Concepts
PEGylationBiodistributionToxicityPharmacokineticsChemistryPharmacologyPEG ratioConjugateTherapeutic indexDrugLinkerPolyethylene glycolBone marrowMedicineBiochemistryImmunologyIn vitroOperating systemComputer scienceMathematicsOrganic chemistryMathematical analysisFinanceEconomicsHER2/EGFR in Cancer ResearchMonoclonal and Polyclonal Antibodies ResearchCell Adhesion Molecules Research