Therapeutic Switching of Rafoxanide: a New Approach To Fighting Drug-Resistant Bacteria and Fungi
Mahmoud M. Bendary, Marwa I. Abd El-Hamid, Amira I. Abousaty, Arwa R. Elmanakhly, Walaa A. Alshareef, Rasha Mosbah, Majid Alhomrani, Mohammed M. Ghoneim, Amr Elkelish, Nada Hashim, Abdulhakeem S. Alamri, Helal F. Al-Harthi, Nesreen A. Safwat
Abstract
The drug repurposing strategy is an alternative approach to reducing drug development timelines with low cost, especially during outbreaks of disease caused by drug-resistant pathogens. Rafoxanide can disrupt the abilities of bacterial and fungal cells to adapt to stress conditions. The coadministration of antibiotics with rafoxanide can prevent the failure of treatment of both resistant bacteria and fungi, as the resistant pathogens could be made sensitive upon treatment with rafoxanide. From our findings, we anticipate that pharmaceutical companies will be able to utilize new combinations against resistant pathogens.