A biocompatible photosensitizer with a high intersystem crossing efficiency for precise two-photon photodynamic therapy
Zhourui Xu, Yihang Jiang, Yuanyuan Shen, Lele Tang, Zulu Hu, Guimiao Lin, Wing‐Cheung Law, Mingze Ma, Biqin Dong, Ken‐Tye Yong, Gaixia Xu, Ye Tao, Runfeng Chen, Chengbin Yang
Abstract
DCz-BSA exhibits excellent biocompatibility, negligible dark toxicity, and superior photostability. Excitation using a femtosecond laser causes BF2DCz-BSA to efficiently generate ROS and precisely exert cell damage at the desired location.
Topics & Concepts
PhotosensitizerPhotodynamic therapyIntersystem crossingBiocompatible materialMaterials sciencePhotonPhotochemistryOptoelectronicsChemistryOpticsBiomedical engineeringMedicinePhysicsAtomic physicsExcited stateOrganic chemistrySinglet stateNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesPhotoacoustic and Ultrasonic Imaging