Presence of tumor-infiltrating CD8 <sup>+</sup> T cells and macrophages correlates to longer overall survival in patients undergoing isolated hepatic perfusion for uveal melanoma liver metastasis
Junko Johansson, Jan Siarov, Roberta Kiffin, Johan Mölne, Jan Mattsson, Peter Naredi, Roger Olofsson Bagge, Anna Martner, Per Lindnér
Abstract
macrophages, correlated to a longer overall survival in patients treated with IHP. Hence, while the immune system of patients with uveal melanoma shows signs of immunosuppression, the presence of activated immune cells may correlate to a longer survival, at least following IHP treatment.
Topics & Concepts
MedicineMelanomaImmune systemCD8MetastasisCD68FOXP3CD163CD14ImmunosuppressionCirculating tumor cellPathologyCancer researchCancerImmunologyMacrophageInternal medicineImmunohistochemistryBiologyIn vitroBiochemistryOcular Oncology and TreatmentsImmunotherapy and Immune ResponsesBladder and Urothelial Cancer Treatments