Protocol and statistical analysis plan for the mega randomised registry trial research program comparing conservative versus liberal oxygenation targets in adults receiving unplanned invasive mechanical ventilation in the ICU (Mega-ROX)

Paul J. Young, Yaseen M. Arabi, Sean M. Bagshaw, Rinaldo Bellomo, Tomoko Fujii, Rashan Haniffa, Carol Hodgson, Bharath Kumar Tirupakuzhi Vijayaraghavan, Edward Litton, Diane Mackle, Alistair Nichol, Jessica Kasza