Novel analgesic/anti-inflammatory agents: 1,5-Diarylpyrrole nitrooxyethyl sulfides and related compounds as Cyclooxygenase-2 inhibitors containing a nitric oxide donor moiety endowed with vasorelaxant properties
M. Saletti, Samuele Maramai, Annalisa Reale, Marco Paolino, Simone Brogi, Angela Di Capua, Andrea Cappelli, Gianluca Giorgi, Danilo D’Avino, Antonietta Rossi, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Roccaldo Sardella, Andrea Carotti, Gerald Woelkart, Burkhard Klösch, Chiara Bigogno, Giulio Dondio, Maurizio Anzini
Topics & Concepts
ChemistryCyclooxygenaseNitric oxideMoietyStereochemistryAnalgesicPharmacologyMedicinal chemistryCombinatorial chemistryEnzymeBiochemistryOrganic chemistryMedicineInflammatory mediators and NSAID effectsOrganic Chemistry Cycloaddition ReactionsEicosanoids and Hypertension Pharmacology