Decreased neuronal synaptosome associated protein 29 contributes to poststroke cognitive impairment by disrupting presynaptic maintenance
Weijie Yan, Jiahui Fan, Xia Zhang, Huimeng Song, Rongqi Wan, Wei Wang, Yanling Yin
Abstract
Since SNAP29 protein levels didn't significantly influence the neuronal survival and its decrease was sufficient to disturb the neural circuit via a presynaptic manner, the SNAP29-associated strategies may be an efficient target against poststroke synaptic dysfunction and cognitive deficits.
Topics & Concepts
Hippocampal formationHippocampusIschemiaNeuroscienceGene knockdownSynaptosomeIn vivoPrefrontal cortexMedicinePatch clampNeurotransmissionCognitionBiologyElectrophysiologyInternal medicineCentral nervous systemReceptorBiochemistryApoptosisBiotechnologyAlzheimer's disease research and treatmentsNeurological Disease Mechanisms and TreatmentsMitochondrial Function and Pathology