Construction of axial chirality by asymmetric alpha C–H alkenylation of aryl alkenes
Cong Shen, Yuhang Zhu, Wenzhou Shen, Shuqi Jin, Liangjun Zhong, Shuxin Luo, Lixia Xu, Guofu Zhong, Jian Zhang
Abstract
An asymmetric α-C–H alkenylation of aryl alkenes has been disclosed to provide axially chiral aryl 1,3-dienes, proceeding through six-membered exo -cyclopalladation, assisted by an aldehyde/ l - t -leucine derived transient chiral auxiliary.
Topics & Concepts
ChemistryArylChirality (physics)AldehydeAlpha (finance)Axial chiralityAxial symmetryStereochemistryMedicinal chemistryEnantioselective synthesisOrganic chemistryCatalysisPhysicsAlkylChiral symmetryNuclear physicsNursingQuarkMedicineQuantum mechanicsNambu–Jona-Lasinio modelConstruct validityPatient satisfactionAxial and Atropisomeric Chirality SynthesisAlkaloids: synthesis and pharmacologyCatalytic C–H Functionalization Methods