Structural, biochemical and bioinformatic analyses of nonribosomal peptide synthetase adenylation domains
Stephanie C. Heard, Jaclyn M. Winter
Abstract
This review highlights the utility of using adenylation domain structural data, biochemical assays, and computational predictions for prioritizing nonribosomal peptide pathways for natural product discovery.
Topics & Concepts
Nonribosomal peptideAdenylylationNatural productComputational biologyPeptideBiologyDomain (mathematical analysis)BiochemistryBiosynthesisChemistryEnzymeMathematical analysisMathematicsMicrobial Natural Products and BiosynthesisBiochemical and Structural CharacterizationRNA and protein synthesis mechanisms