Discovery of seven-membered ring berberine analogues as highly potent and specific hCES2A inhibitors
Yun Yang, Yuan Xiong, Guanghao Zhu, Mengru Sun, Kun Zou, Yitian Zhao, Yong Zhang, Zhijian Xu, Yiming Li, Weiliang Zhu, Qi Jia, Bo Li, Guang‐Bo Ge
Topics & Concepts
BerberineChemistryMoietyStereochemistryIC50AmideSerine hydrolaseSerineEnzymeStructure–activity relationshipBiochemistryIn vitroCholinesterase and Neurodegenerative DiseasesEnzyme function and inhibitionComputational Drug Discovery Methods