Short peptide domains of the Wnt inhibitor sFRP4 target ovarian cancer stem cells by neutralizing the Wnt β-catenin pathway, disrupting the interaction between β-catenin and CD24 and suppressing autophagy
Sumati Sundaram, Lavanya Varier, Khan Zahara Fathima, Arun Dharmarajan, Sudha Warrier
Topics & Concepts
Wnt signaling pathwayCateninAutophagyCell biologyCD24Cancer researchCancer stem cellWestern blotChemistryApoptosisBiologyStem cellSignal transductionBiochemistryGeneWnt/β-catenin signaling in development and cancerAutophagy in Disease and TherapyHedgehog Signaling Pathway Studies