MotiQ: an open-source toolbox to quantify the cell motility and morphology of microglia
Jan N. Hansen, Matthias Brückner, Marie J. Pietrowski, Jan F. Jikeli, Monika Plescher, Hannes Beckert, Mareike Schnaars, Lorenz Fülle, Katharina Reitmeier, Thomas Langmann, Irmgard Förster, Delphine Boche, Gabor C. Petzold, Annett Halle
Abstract
MotiQ is an open-source software for automated quantification of microglial motility and morphology. MotiQ can be applied to in vivo, ex vivo, and in vitro data from confocal, epifluorescence, and two-photon microscopy. MotiQ is not limited to microglia—it can also be applied to other cell types.
Topics & Concepts
BiologyMicrogliaMotilityConfocal microscopyEx vivoCell biologyIn vivoCellFluorescence microscopeConfocalFluorescenceInflammationBiochemistryImmunologyGeometryMathematicsQuantum mechanicsBiotechnologyPhysicsNeuroinflammation and Neurodegeneration MechanismsImmune cells in cancerBarrier Structure and Function Studies