Lymphopenia in Covid-19: A single center retrospective study of 589 cases
El Aidouni Ghizlane, Merbouh Manal, E. Abderrahim, Elrhalete Abdelilah, Mohammed Maarad, Rajae Alkouh, Bouazzaoui Mohammed Amine, Houssam Bkiyar, Naïma Abda, Housni Brahim
Abstract
BACKGROUND: Lymphopenia is one of features that helps identify patients with severe Covid-19. This retrospectively study analyzed the association of lymphopenia with the severity of COVID-19 infection, determinate the predictive factors of lymphopenia and the significance of mortality in patient with lymphopenia. METHODS: 2020. RESULTS: In this study, 589 patients were included, a group had lymphopenia with 357 cases (60.06%) and the non-lymphopenia group with 232 cases (39.4%). The median age of our patients having lymphopenia was 65 years (56-76). Hypertension and diabetes were noted in the majority of patients with lymphopenia than in the non-lymphopenia group. Lymphopenia was strongly correlated to the inflammatory biomarkers of COVID-19 and were significant. A significant correlation was found between lymphopenia group and CT scan. Lymphopenia was observed as an indicator of prolonged duration of hospitalization but was not significant. CONCLUSION: Analytical data from this retrospective study shows the importance in the association between lymphopenia and the severity of COVID-19 infection, hence the need for dynamic monitoring of the number of lymphocytes on admission and during hospitalization of these patients.