Iridium(<scp>iii</scp>)-based minor groove binding complexes as DNA photocleavage agents
Stephen Opeyemi Aderinto, Torsten John, Abdulmujeeb T. Onawole, Raphael Peter Galleh, Jim A. Thomas
Abstract
-analogues. Detailed molecular dynamics simulations confirm that the complexes are groove binders through the insertion of, predominantly, the qtpy ligand into the minor groove. Photoirradiation of 1 in the presence of plasmid DNA confirms that this class of complexes can function as synthetic photonucleases by cleaving DNA.
Topics & Concepts
IridiumMinor grooveChemistryDNADuplex (building)Ligand (biochemistry)Groove (engineering)Excited stateCrystallographyStereochemistryBiochemistryMaterials scienceNuclear physicsCatalysisPhysicsReceptorMetallurgyDNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniquesClick Chemistry and Applications