DNA methylation profiles in cancer: functions, therapy, and beyond
Jinrong Zhu, Yongjie Yang, Li Li, Jiuren Tang, Rongxin Zhang
Abstract
DNA methylation, a reversible post-replication modification, defines gene expression and function in different physiologic processes. Hypomethylation is quite common among global DNA modifications, while promoter hypermethylation often occurs in local regions during cancer, as in CpG island
Topics & Concepts
DNA methylationCpG siteCancerBiologyMethylationDNADNA replicationGeneticsCancer researchComputational biologyGeneGene expressionEpigenetics and DNA MethylationRNA modifications and cancerGenomics and Chromatin Dynamics