Asymmetric hydrogenation of 1,4-diketones: facile synthesis of enantiopure 1,4-diarylbutane-1,4-diols
Jingyuan Song, Pan‐Lin Shao, Jiang Wang, Fanping Huang, Xumu Zhang
Abstract
-amphox as ligand, furnishing a series of 1,4-diarylbutane-1,4-diols in excellent yields (up to >99%) with exceptional enantioselectivities (up to >99.9% ee) and diastereoselectivities (up to >100 : 1 dr).
Topics & Concepts
Enantiopure drugAsymmetric hydrogenationIridiumChemistryLigand (biochemistry)Combinatorial chemistryCatalysisChiral ligandEnantioselective synthesisOrganic chemistryReceptorBiochemistryAsymmetric Hydrogenation and CatalysisSurface Chemistry and CatalysisAsymmetric Synthesis and Catalysis