Oncologic and Safety Outcomes for Retrograde and Antegrade Endoscopic Surgeries for Upper Tract Urothelial Carcinoma: A Systematic Review and Meta-analysis
Ekaterina Laukhtina, Tatsushi Kawada, Fahad Quhal, Takafumi Yanagisawa, Paweł Rajwa, Markus von Deimling, Maximilian Pallauf, Alberto Bianchi, Muhammad Majdoub, Dmitry Enikeev, Harun Fajković, Jeremy Yuen‐Chun Teoh, Morgan Rouprêt, Paolo Gontero, Shahrokh F. Shariat
Abstract
= 89%) for major complications in the retrograde endoscopic cohort. In summary, our analyses suggest promising oncologic benefits of antegrade kidney-sparing surgery in terms of bladder and upper urinary tract recurrence rates in UTUC. Retrograde endoscopic surgery is a safe procedure with a minimal risk of complications and acceptable oncologic outcomes. Research should address the hypothesis that endoscopic antegrade surgery can be a safe and effective alternative for well-selected patients. PATIENT SUMMARY: One of the surgical options for treatment of cancer of the upper urinary tract is removal of the tumor through a small telescope called an endoscope. The endoscope can be inserted via the urethra (called a retrograde approach) or through a small incision in the skin (antegrade approach). Our review shows that the antegrade approach seems to provide acceptable cancer control rates. Further research could help to identify the role for endoscope surgery in cancer of the upper urinary tract.