Genomic Microevolution of <i>Vibrio cholerae</i> O1, Lake Tanganyika Basin, Africa
Yaovi Mahuton Gildas Hounmanou, Elisabeth Njamkepo, Jean Rauzier, Karin Gallandat, Aurélie Jeandron, Guyguy Kamwiziku, Klaudia Porten, Francisco J. Luquero, Aaron Aruna Abedi, Baron Bashige Rumedeka, Berthe Miwanda, Martin Michael, Placide Welo Okitayemba, Jaime Mufitini Saidi, Renaud Piarroux, François‐Xavier Weill, Anders Dalsgaard, Marie‐Laure Quilici
Abstract
Africa's Lake Tanganyika basin is a cholera hotspot. During 2001-2020, Vibrio cholerae O1 isolates obtained from the Democratic Republic of the Congo side of the lake belonged to 2 of the 5 clades of the AFR10 sublineage. One clade became predominant after acquiring a parC mutation that decreased susceptibility to ciprofloxacin.
Topics & Concepts
Vibrio choleraeMicroevolutionCholeraBiologyStructural basinMicrobiologyGeographyGeneticsBacteriaMedicinePaleontologyPopulationEnvironmental healthVibrio bacteria research studiesEvolution and Genetic DynamicsAquatic Ecosystems and Biodiversity