Novel Thienopyrimidine Inhibitors of <i>Leishmania N</i>-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes
Andrew Bell, Zhiyong Yu, J.A. Hutton, Megan H. Wright, J.A. Brannigan, Daniel Paape, S.M. Roberts, Charlotte L. Sutherell, Markus Ritzefeld, Anthony J. Wilkinson, Deborah F. Smith, Robin J. Leatherbarrow, Edward W. Tate
Abstract
NMT over human NMTs.
Topics & Concepts
ChemistryAmastigoteIntracellularLeishmaniaPharmacologyBiochemistryParasite hostingBiologyWorld Wide WebComputer scienceResearch on Leishmaniasis StudiesTrypanosoma species research and implicationsEnzyme function and inhibition