Design, synthesis and biological evaluation of sulfonamides inhibitors of XPO1 displaying activity against multiple myeloma cells
Bingxue Qu, Yongjin Xu, Yang Lu, Weihao Zhuang, Xinxin Jin, Qiuqiu Shi, Shi-Ke Yan, Yu Guo, Zheyuan Shen, Jinxin Che, Yize Wu, Lexian Tong, Xiaowu Dong, Haiyan Yang
Topics & Concepts
ChemistryMultiple myelomaPharmacokineticsDrugPharmacologyBioavailabilityPlasma cellCell growthMicrosomeApoptosisIC50Cell cycleCancer researchIn vitroInternal medicineBiochemistryMedicineMultiple Myeloma Research and TreatmentsProtein Degradation and InhibitorsPeptidase Inhibition and Analysis