Mitochondrial Fusion Protein Mfn2 and Its Role in Heart Failure
Lei Chen, Bilin Liu, Yuan Qin, Anqi Li, Meng Gao, Hanyu Liu, Guohua Gong
Abstract
Mitofusin 2 (Mfn2) is a transmembrane GTPase located on the mitochondrial outer membrane that contributes to mitochondrial network regulation. It is an essential multifunctional protein that participates in various biological processes under physical and pathological conditions, including mitochondrial fusion, reticulum-mitochondria contacts, mitochondrial quality control, and apoptosis. Mfn2 dysfunctions have been found to contribute to cardiovascular diseases, such as ischemia-reperfusion injury, heart failure, and dilated cardiomyopathy. Here, this review mainly focuses on what is known about the structure and function of Mfn2 and its crucial role in heart failure.
Topics & Concepts
MFN2Heart failuremitochondrial fusionMitochondrionBiologyComputational biologyCardiologyChemistryCell biologyMedicineMitochondrial DNAGeneticsGeneMitochondrial Function and PathologyATP Synthase and ATPases ResearchMetabolism and Genetic Disorders